CD36: bridging metabolism, inflammation, and reproduction.

Authors

Qian Liu, Dongyong Yang, Songchen Cai, Yujie Zou, Tailang Yin, Lianghui Diao

Published in

npj metabolic health and disease. Volume 4. Issue 1. Jul 16, 2026. Epub Jul 16, 2026.

Abstract

Reproductive success requires coordinated regulation of metabolism and inflammation across the ovary, uterus, and placenta. CD36 is a lipid transporter and innate immune receptor that couples fatty acid handling to lipid-inflammation crosstalk. We synthesize mechanistic evidence on how CD36 regulates oocyte competence, endometrial receptivity, and signaling at the maternal-fetal interface, and how its dysregulation contributes to gestational diabetes, preeclampsia, and pregnancy loss, suggesting CD36 as a therapeutic target.

PMID:
42463535
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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