Three Rare Cases of Pulmonary Squamous Cell Carcinoma Harboring a KRAS Mutation, Including the Actionable G12C Variant.

Authors

Daiji Ohba, Masafumi Hiratsuka, Hironori Ninomiya

Published in

Pathology international. Volume 76. Issue 7. Pages e70148.

Abstract

KRAS mutations are far less frequent in lung squamous cell carcinoma than in adenocarcinoma. In our institutional series of 136 pulmonary squamous cell carcinomas analyzed using Oncomine Dx Target Test, KRAS G12C mutations were identified only one case (0.8%). Although rare, identification of KRAS G12C mutations in LUSC may expand therapeutic options and support the role of comprehensive molecular profiling in the era of precision oncology.

PMID:
42464637
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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