Synthesis of Large PNA-Encoded Chemical Libraries via Mismatch-Resistant PNA/DNA Hybridization.

Authors

Jun Hyung Park, Jungyeon Kim, Chang Deok Seo, Hee Myeong Wang, Yeongju Lee, Hyun-Suk Lim

Published in

Organic letters. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

Peptide nucleic acid (PNA) offers superior chemical stability relative to DNA, enabling encoded library synthesis under conditions incompatible with conventional DNA-based systems. Here, we report a robust PNA encoding strategy for the construction of large single-pharmacophore PNA-encoded libraries through enhanced discrimination between perfectly matched PNA/DNA duplexes and mismatches. This approach integrates a mismatch-destabilizing codon design with optimized hybridization conditions that selectively favor formation of perfectly matched duplexes.

PMID:
42464820
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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