CD5+ CD10+ lymphoplasmacytic lymphoma with cutaneous histologic transformation in a post-transplant setting.

Authors

Michael T Mulvena, Sam Sadigh, Eric D Jacobsen, Sarah J Wu

Published in

Journal of hematopathology. Volume 19. Issue 1. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

Lymphoplasmacytic lymphoma (LPL) is a lymphoproliferative neoplasm characterized by small plasmacytic cells infiltrating the bone marrow and is typically associated with IgM paraprotein detection. In rare cases, LPL may undergo histologic transformation (HT) to a more aggressive, large B cell lymphoma, such as diffuse large B-cell lymphoma (DLBCL). HT with cutaneous involvement is exceedingly rare. Here, we report a case of cutaneous involvement by a CD5+ CD10+ large B cell lymphoma in a post-transplant setting, initially attributed to follicular lymphoma but determined to be LPL with additional molecular testing. These findings highlight a potential diagnostic pitfall that was resolved by using molecular techniques in tandem with morphological observations.

PMID:
42467117
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.