Balancing act of cytokines in controlling the severity of Clostridioides difficile infection.

Authors

Kevin S Mears, Michael C Abt

Published in

Infection and immunity. Pages e0055125. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

The severity of Clostridioides difficile infection is dictated by a complex interplay of various host cell types and inflammatory mediators responding to the pathogen and surrounding microbiome. An effective immune response must carefully balance controlling C. difficile-mediated pathology and systemic dissemination of opportunistic bacteria while avoiding collateral immunopathology. In addition, a successful immune response must also promote restorative mechanisms to repair toxin-induced disruptions to the intestinal barrier. Here, we review the immune response to C. difficile infection with a specific focus on the role of innate immune-induced cytokines.

PMID:
42467062
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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