Authors
Guangxi Chen, Yawen Zhang, Tao Wang
Published in
Neurogenetics. Volume 27. Issue 1. Jul 17, 2026. Epub Jul 17, 2026.
Abstract
Objective the study investigated the association of rs57095329 polymorphism with Parkinson's disease (PD) susceptibility, clinical features, and miR-146a expression. Methods in this case-control study (204 PD patients, 218 controls), rs57095329 genotype was performed using TaqMan assays. Serum miR-146a expression levels were detected via RT-qPCR. Statistical evaluation included ROC analysis to assess the diagnostic value of miR-146a, Pearson correlation analysis to examine its association with clinical scores (UPDRS-III, H-Y stage, and MoCA), and logistic regression to identify risk factors associated with PD. Results the dominant model genotypes (AG/GG) and the G allele conferred a reduced risk of PD compared to the AA genotype. This protective relevance was more pronounced in individuals aged ≥ 60 years and those with diabetes. Carriers of the AG/GG genotype presented with lower UPDRS-III scores and H-Y staging, together with higher MoCA scores and upregulated miR-146a levels.Serum miR-146a demonstrated outstanding diagnostic accuracy and correlated inversely with PD severity, and was identified as an independent protective factor for PD. Conclusion the miR-146a rs57095329 polymorphism confers reduced susceptibility to PD, with the G allele exerting a protective effect. Reduced serum miR-146a expression was an independent protective marker and shown promising diagnostic value for PD.
PMID:
42467290
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.
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