Authors
Thanin Asawavichienjinda, JianLi Wang
Published in
Pain management. Pages 1-8. Jul 17, 2026. Epub Jul 17, 2026.
Abstract
Psychiatric and medical comorbidities are common in migraine and worsen pain burden and treatment outcomes. We examined the prevalence of comorbidities overall, before and during the COVID-19 pandemic, across migraine subtypes, and identified associated risk factors.
This retrospective comparative cohort study included patients diagnosed with migraine according to the International Classification of Headache Disorders at a tertiary headache center in Thailand. Clinical data were obtained from standardized case record forms and electronic medical records. Comorbidities were self-reported at the initial visit and verified by documented diagnoses. Group differences were analyzed using chi-square or independent t-tests. Multivariable logistic regression identified independent risk factors.
Of the 572 patients, 29.9% had migraine with aura. Overall, 67.7% had at least one comorbidity, and 8.0% had psychiatric comorbidities. During the COVID-19 pandemic, overall and psychiatric comorbidities were more prevalent than in the pre-2020 period (79.4% vs. 66.2% and 17.4% vs. 6.9%, respectively). Chronic migraine was independently associated with comorbidities (adjusted OR 1.67, 95% CI 1.11-2.51), whereas the pre-COVID-19 period was associated with lower odds.
Comorbidities are highly prevalent in migraine, particularly during the COVID-19 pandemic and among patients with chronic migraine. Integrated pain management and routine psychiatric screening may improve comprehensive care.
PMID:
42466919
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.
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