Authors
Magnus Palmblad, Jared M Ragland, Benjamin A Neely
Published in
Journal of proteome research. Jul 17, 2026. Epub Jul 17, 2026.
Abstract
The capabilities of AI-assisted coding are progressing at a breakneck speed. Chat-based vibe coding has evolved into fully fledged AI-assisted, agentic software development using agent scaffolds, where the human developer creates a plan that agentic AIs implement. One current trend is utilizing documents beyond this plan such as project- and method-scoped documents. Here, we propose GROUNDING.md, a community-governed, field-scoped epistemic grounding document, using mass spectrometry-based proteomics as an example. This explicit field-scoped document encodes Hard Constraints (non-negotiable validity invariants empirically required for scientific correctness) and Convention Parameters (community-agreed defaults). In this framework, Hard Constraints are intended to function as field-scoped validity constraints that take precedence over lower-priority context when properly loaded, while Convention Parameters capture community-agreed defaults. In practice, GROUNDING.md will empower a non-domain expert to generate code, tools, and software that have best practices baked in at the ground level, providing confidence to the software developer but also to those reviewing or using the final product. It seems easier to have agentic AIs adhere to guidelines than humans, and this opportunity allows organizations to develop epistemic grounding documents in such a way that keeps domain experts in the loop in a future of democratized generation of bespoke software solutions.
PMID:
42467468
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.
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