[Serial cloners of Yamanashi].

Authors

Bertrand Jordan

Published in

Medecine sciences : M/S. Volume 42. Issue 6-7. Pages 644-647. Epub Jul 17, 2026.

Abstract

Serial cloning of mice by nuclear transfer has been pursued for 20 years and almost 60 successive generations by a highly dedicated Japanese team. Cloning has been successful up to the 57^th generation, although with increasing difficulty from generation 25 onward. Thorough phenotypic and molecular analysis of the successive clones reveals the progressive accumulation of a large number of point mutations and structural variants. This finding has several implications and underlines the necessity of sexual reproduction to ensure continued fitness in successive generations.

PMID:
42466697
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.