[Contributions of seeding amplification assays to the diagnosis of synucleinopathies].

Authors

Emma Lamard, Daisy Bougard

Published in

Medecine sciences : M/S. Volume 42. Issue 6-7. Pages 600-607. Epub Jul 17, 2026.

Abstract

Synucleinopathies comprise three distinct disorders: Parkinson's disease, Lewy body dementia and multiple system atrophy, all of which involve the pathological aggregation of a protein called alpha-synuclein (α-syn). In order to establish an accurate diagnosis of these disorders, and thus improve patient care or inclusion in therapeutic trials, methods based on the in vitro amplification of pathological α-syn have been developed. In this review, we will discuss the history and development of these techniques, their strengths, and the promising prospects they offer for early patient screening using a simple blood sample.

PMID:
42466689
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.