[Tryptophan metabolism: a key player in cardiometabolic diseases].

Authors

Mouna Chajadine, Ludivine Laurans, Soraya Taleb

Published in

Medecine sciences : M/S. Volume 42. Issue 6-7. Pages 590-599. Epub Jul 17, 2026.

Abstract

Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.

PMID:
42466688
Bibliographic data and abstract were imported from PubMed on 17 Jul 2026.

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