Authors
Joyce Liu, Upendra A Argikar, Pietro Brunetti, Maria Chatzopoulou, Sungjoon Cho, Alf Claesson, Deepika Dhaware, Jakob Lang, Bin Ma, Shuguang Ma, Hlaing Maw, Grover P Miller, Simone Schadt, Herana Kamal Seneviratne, Lloyd Wei Tat Tang, Caroline Wei, S Cyrus Khojasteh
Published in
Drug metabolism reviews. Pages 1-34. Jul 17, 2026. Epub Jul 17, 2026.
Abstract
This year marks the fifth installment of the annual review on bioactivation and reactivity. This series evolved from the broader biotransformation and bioactivation review that started a decade ago, reflecting the increasing importance and interest in this area for drug discovery and development. This year's review features 19 articles that reflect the latest findings and advances in bioactivation and reactivity research. This collection of articles is organized into four general themes: (1) mechanistic insights into CYP-mediated bioactivation, enzyme inhibition, and covalent binding, (2) non-CYP-mediated bioactivation, (3) biological drivers of drug-induced toxicity, and (4) advancements in reactive metabolite trapping.
PMID:
42467817
Bibliographic data and abstract were imported from PubMed on 18 Jul 2026.
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