Orthogonal Triple-Click Synthesis of Heteromimetic Triglycosylated Fullerenes.

Authors

Gema Nieto-Ortiz, Jennifer Patino-Alonso, Natalia Honrubia-Rodríguez, Nazario Martín, M Ángeles Herranz, Beatriz M Illescas

Published in

Organic letters. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

Well-defined heteromultivalent glycoarchitectures remain challenging synthetic targets. Herein we report a [60]fullerene hexakis-adduct platform designed to undergo three orthogonally addressable click reactions, allowing the controlled conjugation of three distinct carbohydrates within a single nanostructure. The approach combines thiol-maleimide coupling with two sequential CuAAC transformations using protected and unprotected alkyne handles and supports both stepwise functionalization and one-pot reaction sequences. NMR and DOSY experiments confirmed the integrity and homogeneity of the resulting triple-functionalized glycofullerenes.

PMID:
42467822
Bibliographic data and abstract were imported from PubMed on 18 Jul 2026.

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