Antibacterial, insecticidal, and α-glucosidase inhibitory constituents of Cyclea racemosa Oliv.

Authors

Jing Li, Guiqin Li, Fanrong Yang, Yucheng Huang, Yafeng Wang, Bingyuan Yang, Zhangbin Liu, Lunfa Guo, Biqun Zou, Kedi Yang, Li Ge, Yonglin Huang, Ruijie He

Published in

Natural product research. Pages 1-10. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

Three undescribed isoquinolines, Cycleanoside A (1), (4-methoxybenzyl)-7-hydroxy-8-O-β-D-glucopyranosyl-1-phenoxyisoquinoline (2), and (4-hydroxy-3,5-dimethoxybenzyl)-7-hydroxy-1-benzoate-isoquinoline (3), alongside 21 known compounds, were purified from Cyclea racemosa Oliv. rhizomes (95% ethanol extract). The identification of their structures relied on HR-ESI-MS, NMR experiments, and CD spectroscopic data. Northalifoline (4), steponine (7), p-hydroxybenzaldehyde (11), p-hydroxyphenylacetic acid (12), cinnamic acid (14), and N-trans-feruloyltyramine (15) displayed strong α-glucosidase inhibition, with IC₅₀ values measured between 50 ± 2 and 640 ± 12 μmol/L. Coclaurine (9) showed limited antibacterial potency, and the minimum inhibitory concentrations were determined as 25 μmol/L against Listeria monocytogenes and 51 μmol/L against Staphylococcus aureus, respectively. Cycasin (20) demonstrated potent insecticidal activity against the citrus psyllid at 1 g/L, achieving 56.99 ± 1.92% inhibition.

PMID:
42467885
Bibliographic data and abstract were imported from PubMed on 18 Jul 2026.

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