Ephedplics E-I: three lignans and two benzofuran-type compounds from the roots of Ephedra sinica Stapf and their neuroprotective activity.

Authors

Yunlong Dou, Bowen Zhang, Meng Li, Xiaolan Wang, Shuyan Liu, Yanjun Sun, Xiaoke Zheng, Weisheng Feng

Published in

Journal of natural medicines. Jul 17, 2026. Epub Jul 17, 2026.

Abstract

Five new compounds Ephedplics E-I were isolated from the roots of Ephedra sinica Stapf, including three lignans (1-3) and two benzofuran-type compounds (4-5). Their structures were elucidated by spectroscopic methods, involving UV, IR, NMR spectra and HRESIMS analyses. The absolute configuration of compounds 1-5 was determined by comparing their experimental and calculated ECD spectra. All compounds were assessed for their neuroprotective activities against damage induced by corticosterone (CORT) in PC-12 cells. Compounds 1 and 2 were capable of significantly ameliorating CORT-induced PC-12 injury.

PMID:
42469578
Bibliographic data and abstract were imported from PubMed on 18 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.