Characterization of immunomodulatory dialkylresorcinols from the human-associated HACEK bacteria.

Authors

Jiangnan Xia, Juan Liang, Yan Luo, Yu Sun, Chen Niu, Tian Xu, Lihan Zhang

Published in

Communications chemistry. Jul 18, 2026. Epub Jul 18, 2026.

Abstract

Endogenous metabolites from the human microbiome play a crucial role in human health and disease. Their involvement in immune and inflammatory regulatory processes both under physiological conditions and diseases renders them essential for pathological research and therapeutic development. However, the microbial metabolites that mediate interactions between the host and microbiome remain largely undefined. Here, we explored a group of ketoacyl synthases from Eikenella spp. that constitute the HACEK group of human opportunistic pathogens through global genome mining. In vivo and in vitro verification of these enzymes resulted in the production of three dialkylresorcinols, which were found to act as agonists of the aryl hydrocarbon receptor and reduce the inflammatory factors of multiple immune cells. These results demonstrate that human-associated Eikenella spp. are capable of producing bioactive aromatic polyketides, which may suggest a molecular mechanism of immunomodulation by the human microbiota.

PMID:
42471503
Bibliographic data and abstract were imported from PubMed on 19 Jul 2026.

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