Single-cell technologies in mRNA cancer vaccines.

Authors

Ekaterina V Ovcharenko, Marina R Patysheva, Kirill M Kirilenko, Arina A Ibragimova, Evgeny V Denisov

Published in

NPJ vaccines. Jul 18, 2026. Epub Jul 18, 2026.

Abstract

The fast evolution of mRNA-based cancer therapeutics requires advanced frameworks to overcome the challenges of tumor heterogeneity and the immunosuppressive tumor immune microenvironment. In this context, single-cell technologies enable characterization of immune cell subsets, intercellular communication, and therapy resistance drivers. The shift to single-cell profiling provides a transition toward the development of precision mRNA treatments tailored to the unique dynamics of an individual tumor.

PMID:
42471337
Bibliographic data and abstract were imported from PubMed on 19 Jul 2026.

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