EID1 overexpression in brown adipose tissue enhances cold-induced thermogenesis in male mice.

Authors

Itsuki Takahashi, Diana Vargas, Yusuke Watanabe, Tomohiko Sato, Mitsue Miyazaki, Hirofumi Hanaoka, Takahito Nakajima, Ryosuke Kaneko, Izuki Amano, Takeo Nakanishi, Fernando Lizcano, Noriyuki Koibuchi, Noriaki Shimokawa

Published in

iScience. Volume 29. Issue 8. Pages 116703. Aug 21, 2026. Epub Jul 11, 2026.

Abstract

E1A-like inhibitor of differentiation 1 (EID1), a nuclear coregulator, has been implicated in adipocyte differentiation and lipid metabolism. In vitro, EID1 overexpression suppresses lipid accumulation in preadipocytes; however, its role in thermogenesis in vivo remains unclear. We generated adipose tissue-specific EID1 transgenic (Tg) mice and assessed their thermogenic capacity under cold exposure. During cold exposure, male Tg mice exhibited more than a 7-fold increase in interscapular brown adipose tissue (BAT) glucose uptake, nearly triple the response observed in wild-type (Wt) mice. Core body temperature was better maintained in Tg mice, with attenuated cold-induced decline. Infrared thermography revealed a 5-fold greater increase in BAT temperature in Tg mice than in the Wt controls. These responses were accompanied by robust upregulation of thermogenesis-related genes. These findings highlight EID1 as a dynamic regulator of thermogenic capacity and suggest that modulating its stability and activity may represent a new strategy to improve metabolic health.

PMID:
42472102
Bibliographic data and abstract were imported from PubMed on 19 Jul 2026.

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