Authors
Seungtae Kim, Jeong-Kui Ku, Yongjun Cho, Jae-Young Kim, Jong-Ki Huh
Published in
Tissue engineering and regenerative medicine. Jul 19, 2026. Epub Jul 19, 2026.
Abstract
Autogenous tooth bone graft (AutoBT), derived from extracted teeth, has emerged as a promising alternative for bone regeneration due to its osteoinductive and osteoconductive properties. Its structural and compositional similarity to bone supports physiologic bone regeneration, and it has been successfully applied in various clinical procedures. However, despite its increasing clinical application, evidence regarding the long-term outcomes of AutoBT in large cystic defects remains limited.
A 22-year-old woman presented with a 4-cm multilobular radiolucent lesion in the left mandible that was diagnosed as an odontogenic keratocyst (OKC). Following a period of decompression, cyst enucleation and bone grafting were performed using AutoBT combined with recombinant human bone morphogenetic protein-2 (rhBMP-2). Radiographic follow-up at 1.5 months, 1 year, and 3 years postoperatively demonstrated stable bone remodeling, reestablishment of the cortico-cancellous architecture, and no evidence of recurrence. The postoperative clinical course was uneventful.
This case demonstrates successful long-term bone regeneration using AutoBT combined with rhBMP-2 in a large mandibular OKC defect. Although limited to a single case, these findings support the potential of AutoBT combined with rhBMP-2 as a reliable graft material for extensive jawbone lesions. Further studies are needed to validate its long-term efficacy and safety.
PMID:
42472412
Bibliographic data and abstract were imported from PubMed on 19 Jul 2026.
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