Authors
Elham Khayer Damirchi, Amin Barani, Seyyed Mohammad Hamidi, Mohammad Ali Ebrahimzadeh
Published in
European journal of medicinal chemistry. Volume 318. Pages 119156. Jul 16, 2026. Epub Jul 16, 2026.
Abstract
Compound hybridization has received attention due to its potential to address several diseases, including neurological disorders, cancer, infectious diseases, and others. Melatonin is a hormone with antioxidant, anti-inflammatory, and neuroprotective effects. Some drug design research has focused on synthesizing hybrid molecules in which melatonin is hybridized with other pharmacologically active compounds to increase therapeutic efficacy and reduce toxicity. These hybrids demonstrate improved binding affinity, selectivity, and pharmacokinetic characteristics compared to their separate components. This review shows the pharmacological assessment and therapeutic potential of diverse melatonin-based hybrids. These hybrids have exhibited significant efficacy in the treatment of complex diseases such as Alzheimer's disease, cancer, and inflammatory disorders. Hybridization leads to the synthesis of a new generation of structures that represent a promising therapeutic approach for disease treatment.
PMID:
42472492
Bibliographic data and abstract were imported from PubMed on 20 Jul 2026.
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