Calcium-releasing silica-coated cellulose nanofiber aerogel for safe and efficient hemostasis.

Authors

Lei Chen, Ruicai Xia, Zhiping Jin, Wei Li, Guodong Wang, Qiang Zhang

Published in

Biomaterials advances. Volume 188. Pages 215061. Jul 19, 2026. Epub Jul 19, 2026.

Abstract

Severe hemorrhage remains a leading cause of preventable death in trauma and surgical settings, underscoring the ongoing need for topical hemostats that offer rapid coagulation, robust retention, and a favorable safety profile. Here we report a calcium-releasing silica-modified cellulose nanofiber (Ca-SCNF) aerogel fabricated via a Pickering emulsion-templated approach. In this design, carboxymethyl cellulose nanofibers function both as the scaffold-forming matrix and as the template for silica-based surface modification, with Ca²⁺ incorporated as a releasable pro-coagulant component. The resulting Ca-SCNF aerogel exhibits a lightweight, highly porous structure, with negligible hemolysis (<1%), minimal heat generation and limited particle detachment. When exposed to platelet-poor plasma, Ca-SCNF aerogel increases detectable Ca²⁺ availability and promotes plasma coagulation under direct material contact. In a rat femoral artery transection model, Ca-SCNF aerogel significantly reduces hemostasis time and blood loss relative to cotton and QuikClot Combat Gauze. These findings establish Ca-SCNF aerogel as a safe and effective hemostatic agent that outperforms natural inorganic mineral-based counterparts.

PMID:
42472493
Bibliographic data and abstract were imported from PubMed on 20 Jul 2026.

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