Association between disease duration, severity, and treatment outcome of office-based blue laser therapy for benign vocal fold lesions.

Authors

Abdul-Latif Hamdan, Ghena Lababidi, Lana Ghzayel, Valerie Sarkis, Patrick Abou Raji Feghali, Ibana Carapiperis, Elie Alam, Marc Mourad, Jerome R Lechien

Published in

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Jul 19, 2026. Epub Jul 19, 2026.

Abstract

To analyze whether disease duration and severity can predict voice quality improvement following office-based blue laser therapy (OBLT) for benign lesions of the vocal folds.
Retrospective chart review.
Medical records of patients with benign lesions of the vocal folds who underwent OBLT between November 2023 and December 2025 were reviewed. Demographic data included age, gender, history of smoking, reflux disease, voice abuse, diagnosis, follow-up period, and disease duration. Self-perceived disease severity was assessed using the Voice Handicap Index-10 (VHI-10) and the Visual Analog Scale (VAS). Secondary outcome measures included acoustic and aerodynamic parameters.
Sixty patients were included (35 females, mean age: 52.35 ± 14.45). The mean disease duration was 15.35 ± 20.80 months. Linear regression analysis showed no association between disease duration and mean change in VHI-10 (r = 0.018, p = 0.901) or VAS scores (r = 0.021, p = 0.886). There was a strong significant association between pre-operative VHI-10 score and mean change in VHI-10 (r = 0.681, p < 0.001) and the mean change in VAS scores (r = 0.636, p < 0.001), and between pre-operative VAS scores and mean change in VHI-10 (r = 0.642, p < 0.001) and the mean change in VAS scores (r = 0.758, p < 0.001). A weak positive significant association was found between pre-operative VAS scores and mean change in percent jitter (r = 0.271, p = 0.040). No significant associations were observed between disease duration, disease severity, and other acoustic or aerodynamic parameters.
Disease severity and not disease duration was associated with self-perceived improvement in voice quality following office-based blue laser therapy for benign vocal fold lesions.

PMID:
42472920
Bibliographic data and abstract were imported from PubMed on 20 Jul 2026.

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