Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model.

Authors

Rohit Shetty, Pooja Khamar, Gairik Kundu, Panaah Shetty, Deepthi Honniganur, Abha Shah, Raghav Narasimhan, Abhijit Sinha Roy

Published in

Clinical ophthalmology (Auckland, N.Z.). Volume 20. Pages 619163. Epub Jul 15, 2026.

Abstract

To assess corneal tomography changes in keratoconus (KC) patients after long-term simultaneous use of topical cyclosporine and trehalose.
Retrospective observational study.
Corneal tomography of 362 eyes with KC was performed using Pentacam (OCULUS Optikgerate Gmbh, Germany) at 1^st visit and at the last follow-up. Progression was initially evaluated based on change in maximum keratometry (Kmax). This initial classification was then assessed with an artificial intelligence model of 31 tomography variables of Pentacam to confirm the inference of progression based on Kmax alone.
The mean follow-up time was 10.8 ± 6.01 months (range: 6 to 36 months). Based on a change in Kmax of 0.75, 1.0 and 1.25D criteria, more than 90% of the eyes were stable for each criterion at the last follow-up (initial classification). The AI model confirmed stability of corneal tomography in more than 95% of the eyes at the last follow-up (final classification).
Most KC eyes had stable tomography findings between the first and last follow-up. Topical anti-inflammatory regimens may be useful for minimizing or eliminating KC progression.

PMID:
42473651
Bibliographic data and abstract were imported from PubMed on 20 Jul 2026.

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