Authors
Meiyan Liu, Yuquan Chen, Pin Xie, Weijie Xu, Shuiwen Huang, Baorong Liu
Published in
Infection and drug resistance. Volume 19. Pages 624063. Epub Jul 15, 2026.
Abstract
Listeria monocytogenes (LM) meningitis is a rare but severe infection, particularly in immunocompromised patients, often leading to complications such as hydrocephalus, markedly increasing treatment complexity and the risk of poor outcomes.
We report a case of LM meningitis in an immunocompromised patient. The illness began with fever and gastrointestinal symptoms, followed by neck stiffness and altered consciousness. LM was identified via blood culture, cerebrospinal fluid (CSF) culture, and metagenomic next-generation sequencing (mNGS). During hospitalization, the patient developed decompensated hydrocephalus and a right occipital lobe infarction, emergent external ventricular drainage (hospital day 4) and subsequent ventriculoperitoneal shunting (hospital day 44) were performed, which were potentially life-saving. After comprehensive treatment and rehabilitation, the patient was discharged on day 85 without significant neurological deficits.
Clinical presentation of LM meningitis may be atypical, especially in immunocompromised patients. In such patients, aggressive management of hydrocephalus-including timely CSF diversion-is potentially life-saving. Early pathogen detection through combined blood culture, CSF culture, and mNGS, together with prompt, targeted antimicrobial therapy and dynamic management of neurological complications such as hydrocephalus, is essential for improving clinical outcomes.
PMID:
42473611
Bibliographic data and abstract were imported from PubMed on 20 Jul 2026.
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