The strip-shaped deep white matter hyperintensities may be related to neurodegeneration: A study based on diffusion tensor imaging.

Authors

Xuexia Sheng, Long Xu, Donghua Xu, Daihai Yuan, Wenchao Xie, Jiyuan Ge, Yizhi Zhao, Chaoyue Yang, Zhigang Min

Published in

PloS one. Volume 21. Issue 7. Pages e0354301. Epub Jul 20, 2026.

Abstract

This study investigated the properties of strip-shaped white matter hyperintensities (WMHs) by examining the relationship between their principal axes and maximum diffusion direction, and comparing their diffusion tensor metrics with punctate and early confluent WMHs to explore their pathological features and potential link to chronic axonal injury.
Eighty-seven participants with isolated WMHs were included and received diffusion tensor imaging (DTI) using a 3.0-T MR scanner. Lesions were classified by elongation (strip-shaped: ≥ 2; punctate: < 2). We recorded the maximum diffusion direction of punctate, strip-shaped, and early confluent WMHs and evaluated their consistency with the principal axial direction. Additionally, the diffusion tensor metrics of strip-shaped WMHs were measured and compared with those of punctate and early confluent WMHs.
Among 996 WMHs, 57.5% of strip-shaped lesions showed principal axis alignment with the maximum diffusion direction, significantly higher than punctate (44.7%) and early confluent (42.1%) lesions (P < 0.05). Mixed-effects models showed significant lesion type effects on FA, MD, AD, and RD (all P < 0.05). Post-hoc comparisons revealed that stripe lesions had higher FA but lower MD and RD than confluence lesions (all P < 0.05), with no significant differences between stripe and punctate groups for MD or RD. No AD differences were found among groups. Fiber tracking confirmed alignment in most strip-shaped lesions.
Strip-shaped WMHs exhibit unique diffusion metrics and fiber alignment, suggesting chronic axonal injury due to neurodegeneration. These findings underscore the importance of morphological and microstructural analysis in understanding WMH heterogeneity and clinical significance.

PMID:
42475321
Bibliographic data and abstract were imported from PubMed on 21 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.