Nocturnal enuresis in children with allergic disease: prevalence, phenotype, and ARIA severity analysis.

Authors

Şefika İlknur Kökçü Karadağ, Bahar Eda Küçük, Aslı Berivan Topçak, Muhammed Fatih Erbay, Çağla Öztürk Turhan, Nilay Çalışkan, Hamit Boloğur, Merve Karaca Şahin, Hasan Tunç Şarman, Hilal Güngör, Güler Yıldırım, Hasan Dursun, Deniz Özçeker

Published in

International urology and nephrology. Jul 21, 2026. Epub Jul 21, 2026.

Abstract

To determine the prevalence of primary nocturnal enuresis (PNE) in children with allergic disease, characterize the allergic symptom burden in children with PNE, and identify clinical phenotype differences between allergic and nonallergic enuretic children.
300 children aged 5-18 years were enrolled in three groups: a specialist-confirmed allergic disease cohort (Group 1, n = 100), a nephrologist-confirmed PNE cohort (Group 2, n = 100), and a general pediatric comparison group (Group 3, n = 100). Clinical phenotype was systematically compared between allergic enuretic children and enuretic children from the comparison group. Allergic Rhinitis and its Impact on Asthma (ARIA) classification severity classification was applied in children with allergic rhinitis as a pre-specified exploratory analysis.
PNE prevalence was 1.7-fold higher in allergic children than in the comparison group (27.0% vs 16.0%; OR: 1.94, 95% CI 0.97-3.88, p = 0.060). Allergic enuretic children showed a phenotypically distinct profile: shorter enuresis duration (2.0 vs 3.0 years, p = 0.028), higher nocturnal sleep disturbance (36.0% vs. 6.7%, p = 0.060), and lower rates of stress-related exacerbation (34.6% vs. 75.0%, p = 0.025) compared with enuretic children from the comparison group. ISAAC-based screening in the PNE cohort revealed a substantial allergic symptom burden: wheezing in 45.0%, inhaler use in 33.0%, and allergic rhinitis symptoms in 22.0%. An exploratory monotonic gradient in PNE prevalence was observed across ARIA severity categories (ARIA-1: 12.5%, ARIA-2: 25.0%, ARIA-3: 33.3%; p = 0.172).
Allergic enuretic children display a distinct sleep-associated clinical phenotype, and a notable allergic symptom burden is present in children with PNE. These findings support asking about nocturnal enuresis in allergic children and considering allergy-focused evaluation in selected PNE patients in general pediatric practice.

PMID:
42479373
Bibliographic data and abstract were imported from PubMed on 21 Jul 2026.

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