The emerging role of ERphagy/reticulophagy in pathogen invasion.

Authors

Damian Gatica, Daniel J Klionsky

Published in

Autophagy. Volume 22. Issue 8. Pages 1743-1744. Epub Jul 21, 2026.

Abstract

In recent years ERphagy, the selective autophagic degradation of the endoplasmic reticulum (ER), has emerged as a key selective autophagic pathway involved not only in the recycling of the ER, but also in preventing the replication of viruses and bacteria. The mechanisms by which ERphagy achieves this do not seem immediately related to canonical xenophagy pathways and could provide a new avenue for therapeutic targets to combat pathogenic infections. In this editor's corner we briefly summarize the ways ERphagy is involved in pathogen infection, highlighting the potential ERphagy has as an understudied innate immune response pathway.Abbreviation: IFN-I: type I interferon; LPS: lipopolysaccharide; STING1: stimulator of interferon response cGAMP interactor 1.

PMID:
42480033
Bibliographic data and abstract were imported from PubMed on 22 Jul 2026.

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