Authors
Kenneth L Urish, Samuelson E Osifo, Jonathan D Steckbeck
Published in
The Journal of bone and joint surgery. American volume. Jul 21, 2026. Epub Jul 21, 2026.
Abstract
➢ Peptides lack a rigid tertiary structure, allowing them to adopt a variety of conformations, and can be engineered for specific targets. This article examines the design principles underlying orthopaedic peptide applications, from preclinical candidates to clinically validated drugs.➢ The use of peptides in orthopaedics began with naturally occurring agents, such as bone morphogenetic proteins, and has evolved toward rationally engineered synthetics.➢ Teriparatide, a synthetic parathyroid hormone-derived peptide, is used for bone regeneration; PLG0206, a fully engineered antimicrobial peptide, has demonstrated activity against biofilm-forming and multidrug-resistant organisms that conventional antibiotics cannot eradicate, and is advancing through Phase-II and III clinical evaluations.➢ Peptide engineering has produced candidates with potential for cartilage-penetrating, sustained local drug delivery, although no peptide-based disease-modifying osteoarthritis drug has yet achieved clinical validation.➢ Artificial intelligence-driven peptide design is accelerating discovery, but the translation of computationally designed sequences to clinical efficacy remains an active challenge.
PMID:
42479819
Bibliographic data and abstract were imported from PubMed on 22 Jul 2026.
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