Authors
Songming Ding, Di Wang, Yiting Hu, Shusen Zheng, Qiyong Li, Weiqing Luo
Published in
Journal of surgical case reports. Volume 2026. Issue 7. Pages rjag625. Epub Jul 22, 2026.
Abstract
Perihilar cholangiocarcinoma (pCCA), originating from the second-order bile ducts and extending to the cystic duct insertion, is the most common cholangiocarcinoma subtype and carries a dismal prognosis. It is typically characterized by obstructive jaundice and elevated serum carbohydrate antigen 19-9 (CA19-9); however, these features significantly overlap with those of benign biliary diseases. While endoscopic retrograde cholangiopancreatography-guided tissue sampling is crucial for diagnosis, its sensitivity remains suboptimal. Consequently, up to 15% of preoperatively suspected pCCA cases are confirmed as benign strictures postoperatively. Given the close association between choledocholithiasis and pCCA, distinguishing malignancy from stone-induced inflammatory disease remains a significant diagnostic challenge. Herein, we report a rare case of chronic cholangitis mimicking pCCA, ultimately attributed to calculi containing a retained foreign body.
PMID:
42488930
Bibliographic data and abstract were imported from PubMed on 23 Jul 2026.
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