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Applications of Prolotherapy in Chronic Musculoskeletal Pelvic Pain: A Narrative Review.

Created on 23 Jul 2026

Authors

Annie M Cho, R Jason Yong, Samuel P Ang

Published in

Current pain and headache reports. Volume 30. Issue 1. Jul 23, 2026. Epub Jul 23, 2026.

Abstract

Though the utilization of prolotherapy has been described since the 1930s, there still exists a paucity of information about its contemporary application as an alternative or complementary treatment modality for chronic musculoskeletal pelvic pain.
Prolotherapy may serve as a safe and efficacious nonsurgical intervention for the treatment of a multitude of chronic pelvic pain conditions, particularly in cases where conservative medical management and physical therapy have failed. In this narrative review, we discuss the current evidence suggesting that prolotherapy is effective in the treatment of various pain conditions involving the musculoskeletal structures of the pelvis such as sacroiliac joint pain, coccydynia, deep gluteal syndrome, and chronic groin pain. Future prospective clinical studies are necessary to better define and characterize the role of prolotherapy as a mainstay of treatment for chronic pelvic pain.

PMID:
42489756
Bibliographic data and abstract were imported from PubMed on 23 Jul 2026.

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