Multi-omics reveals that streptomycin sulfate induces obesity in Halyomorpha halys by disrupting the gut microbiome-metabolome axis.

Authors

Xiaoyu Yan, Yaquan Lv, Dianyu Liu, Yu Chen, Zhihan Su, Wenyan Xu, Xiaolin Dong, Chenxi Liu

Published in

iScience. Volume 29. Issue 7. Pages 116612. Jul 17, 2026. Epub Jun 30, 2026.

Abstract

The global obesity epidemic is linked to antibiotic exposure, yet mechanisms remain unclear. We found that streptomycin sulfate (SM) exposure induced obesity in Halyomorpha halys. Using a multi-omics approach (16S rRNA sequencing, metabolomics, and transcriptomics), we demonstrated that SM restructured the gut microbiome in a sex-specific manner and dysregulated key metabolic pathways. Integrated analysis revealed a robust network linking altered gut bacteria, disrupted metabolites, and host transcriptional responses. Our findings establish that SM promotes obesity by disrupting the gut microbiome-metabolome interface, providing mechanistic insights into antibiotic-induced metabolic dysfunction.

PMID:
42491906
Bibliographic data and abstract were imported from PubMed on 24 Jul 2026.

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