Association between the Atherogenic Index of Plasma and in-Hospital Mortality in Individuals with Sepsis.

Authors

Peng Li, Xiujun Zhu, Weiguo Zheng, Li Zhang, Li Liu

Published in

Yonsei medical journal. Volume 67. Issue 8. Pages 639-648.

Abstract

Numerous studies have shown that the atherogenic index of plasma (AIP) is a strong predictor of the risk of cardiovascular diseases (CVDs) and an independent predictor of cardiovascular events (CEs) and related mortality. The predictive value of AIP for in-hospital mortality (IHM) in individuals with sepsis remains uncertain. Therefore, this study aimed to investigate the association between AIP and IHM among patients with sepsis using a large sample from the Medical Information Mart for Intensive Care (MIMIC) database.
Individuals with sepsis were identified from the MIMIC-IV database and categorized into four groups according to AIP quartiles. The IHM was the primary outcome. The association between AIP and IHM was evaluated using logistic regression and restricted cubic spline (RCS) models.
A total of 2243 patients (59% male) were included this study. In univariable logistic regression, higher AIP was significantly associated with increased IHM (odds ratio: 1.18 [95% confidence interval: 1.05-1.33]; p of Wald test=0.005). The RCS model showed no evidence of a nonlinear association between AIP and IHM (p for nonlinearity>0.05). Sensitivity analysis demonstrated consistent findings regarding the magnitude and direction of the effects across different subgroups, indicating stable results.
Elevated AIP was associated with higher IHM in individuals with sepsis.

PMID:
42494271
Bibliographic data and abstract were imported from PubMed on 24 Jul 2026.

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