Medical Treatment or Intervention for Asymptomatic Carotid Stenosis? Interpreting CREST-2.

Authors

Peter Kelly, John McCabe, Gert Jan De Borst

Published in

Stroke. Jul 24, 2026. Epub Jul 24, 2026.

Abstract

Older randomized trials have shown modest benefit for carotid endarterectomy for selected patients with asymptomatic carotid stenosis compared with medical treatment. However, improvements in contemporary medical therapy may have negated the benefit of carotid endarterectomy, and no large randomized trials comparing stenting with modern medical treatment have been completed. The recently reported CREST-2 trial addressed these evidence gaps. We describe the main results of CREST-2 and our interpretation of the findings for clinical practice.

PMID:
42495730
Bibliographic data and abstract were imported from PubMed on 24 Jul 2026.

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