Isolation, characterisation, and anti-inflammatory activities of constituents from Viburnum macrocephalum f. macrocephalum leaves.

Authors

Ya-Jiao Chen, Yi-Yuan Tang, Hong-Juan Zhou, Jia Chen, Jian-Hua Shao, Chun-Chao Zhao

Published in

Natural product research. Pages 1-6. Jul 24, 2026. Epub Jul 24, 2026.

Abstract

From Viburnum macrocephalum f. macrocephalum leaves (VMML), three new iridoids, viburetins A-C (1-3), together with four previously reported constituents, were isolated following a phytochemical investigation. Structural elucidation of the new isolates was achieved via detailed spectroscopic analyses (1D/2D NMR, HRESIMS) coupled with ECD experiments. The suppression of nitric oxide (NO) generation in RAW264.7 murine macrophages stimulated by LPS was assessed to determine anti-inflammatory effects of these isolates. Notably, compound 2 exhibited potent suppressive effects on NO generation (IC₅₀ = 5.39 μM). Furthermore, molecular docking studies showed that compound 2 could effectively bind to the catalytic cavities of iNOS/COX-2 via hydrogen bonds and hydrophobic interactions. These results suggested that VMML containing these constituents possessed promising anti-inflammatory activity.

PMID:
42497009
Bibliographic data and abstract were imported from PubMed on 25 Jul 2026.

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