Beyond the Major Determinant: Patterns of Penicillin Skin Test Positivity.

Authors

Ingrid Salciccioli, Andrew J King, John J O Accarino, Ami Belmont, Olajumoke O Fadugba, Alexei Gonzalez-Estrada, David A Khan, Anne Liu, Iris M Otani, Elizabeth J Phillips, Allison Ramsey, Cosby A Stone, Aleena Banerji, Kimberly G Blumenthal, USDAR Study Team

Published in

The journal of allergy and clinical immunology. In practice. Jul 24, 2026. Epub Jul 24, 2026.

Abstract

Penicillin G and aminopenicillins skin testing identified nearly 90% of penicillin allergic patients, suggesting PREPEN is not essential for most evaluations and can be reserved for high-risk patients during shortages. Current skin testing strategies remain clinically valuable even without PPL, while direct oral challenge stays preferred for low-risk patients.

PMID:
42498127
Bibliographic data and abstract were imported from PubMed on 25 Jul 2026.

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