Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp.

Authors

Shotaro Hoshino, Emiko Nagai, Hisayuki Komaki, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka

Published in

The Journal of antibiotics. Jul 24, 2026. Epub Jul 24, 2026.

Abstract

Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, and the structure of 2 was further confirmed by chemical synthesis. Based on disk diffusion and broth microdilution assays using the synthetic material, 2 exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeast.

PMID:
42498785
Bibliographic data and abstract were imported from PubMed on 25 Jul 2026.

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