Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases.

Authors

Chensi Yao, Wei Zheng, Yamei Jin, Jiahao Sheng, Mengjiao Kang, Jijuan Zhong, Min Li, Liyun Duan, Xiao Yuan

Published in

Frontiers in immunology. Volume 17. Pages 1819389. Epub Jul 10, 2026.

Abstract

Obesity and its associated metabolic disorders constitute a prominent public health challenge. Diverse environmental and metabolic cues trigger alterations in macrophage metabolism, thereby influencing their functional phenotypes. Due to their phenotypic plasticity, macrophages play beneficial roles in tissue homeostasis, yet they also contribute to the progression of metabolic diseases. Consequently, beyond systemic chronic low-grade inflammation, greater attention should be directed toward immunometabolic dysfunction in metabolic tissues during obesity and its related diseases. This review summarizes the functional phenotypes and metabolic characteristics of macrophages, with an emphasis on how tissue niches influence macrophage function in the context of various obesity-related metabolic diseases. Enhanced understanding of the interplay between macrophages and metabolic target organs/tissues may provide novel therapeutic strategies for managing obesity and associated metabolic disorders.

PMID:
42500673
Bibliographic data and abstract were imported from PubMed on 25 Jul 2026.

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