Authors
Nicole Touriel Bornsztein, Ariela Grabarz, Ana Laura Donaire Rapozero, Roberta Facchini Jardim Criado, Paulo Ricardo Criado, Gabriela Izzo Luiz, Luisa Homem de Mello Maciel Campilongo, Denise Maria Christofolini
Published in
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. Volume 48. Epub Jul 17, 2026.
Abstract
Autoimmune progesterone dermatitis (APD) is a rare hypersensitivity to high levels of progesterone, with an as-yet unknown etiology. The objective of this study is to gather epidemiological data on patients with APD at an outpatient dermatology clinic.
Medical records of patients diagnosed with APD, from menarche to menopause, seen at the dermatology clinic between 2004 and 2020 were reviewed.
Thirteen patients with APD were included. The mean age of symptom onset among APD patients was 24 years. The most prevalent clinical manifestation was urticaria, and the most common associated symptom was pruritus. The perimenstrual period was the most frequent aggravating factor, reported in 100% of cases. The intradermal progesterone test and autologous serum skin test were positive in approximately 60% of cases.
Autoimmune progesterone dermatitis is an important differential diagnosis in female patients with dermatitis and should be considered during clinical evaluations.
PMID:
42500193
Bibliographic data and abstract were imported from PubMed on 25 Jul 2026.
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