Reference intervals for plasma renin and aldosterone concentrations in healthy normotensive multi-ethnic Malaysian adults using DiaSorin chemiluminescent immunoassay.

Authors

Siow Phing Tay, Huai Heng Loh, Arlizan Baizura Ariffin, Anselm Ting Su, Nurul Farhana Satar, Ttarcini Engatramana, Mohammad Izzad Ishak, Simon Heng Haut Su, Liwan Lasem, Norliza Samsuri, Chee Shee Chai, Mohammad Masrin Md Zahrin, Jun Jun Thien, Xun Ting Tiong, Florence Hui Sieng Tan, Elena Aisha Azizan, Norlela Sukor

Published in

Clinical biochemistry. Pages 111175. Jul 25, 2026. Epub Jul 25, 2026.

Abstract

Accurate interpretation of plasma renin concentration (PRC) and plasma aldosterone concentration (PAC) requires population-specific reference intervals, which remain scarce in Southeast Asian populations. Manufacturer-derived reference intervals are based predominantly on Western cohorts and may not be directly applicable to regional populations.
This cross-sectional study recruited 300 healthy, normotensive, non-obese adults (149 males, 151 females; mean age 34.4 ± 10.7 years) from a multi-ethnic Malaysian cohort in Sarawak to establish reference intervals for PAC and PRC. Strict exclusion criteria were applied to minimize confounding from medications, smoking, obesity, renal dysfunction, and hypokalemia. PAC and PRC were measured under standardized seated morning conditions using the DiaSorin Liaison® XL chemiluminescent immunoassay (CLIA). Reference intervals were derived using the IFCC-recommended non-parametric method, with sex- and age-stratified analyses.
The reference intervals were 2.13-30.1 ng/dL (2.5th to 97.5th percentile) for PAC (range 1.25-42.30 ng/dL) and 7.4-66.4 μIU/mL (5th to 95th percentile) for PRC (range 1.31-107.80 μIU/mL). Participants aged ≥40 years had significantly lower PAC and PRC than younger participants. On multivariable regression analysis, PAC was independently associated with serum potassium and estimated 24-h urine sodium excretion, whereas PRC was independently associated with age, sex, systolic blood pressure, and estimated 24-h urinary sodium excretion. No significant difference in PAC and PRC was observed across ethnic groups.
We report the first platform-specific, sex- and age-stratified reference intervals for PAC and PRC in a healthy Southeast Asian population using the DiaSorin Liaison® XL CLIA platform. The derived intervals differed from manufacturer-provided values, highlighting the importance of locally validated reference data for accurate interpretation of RAAS biomarkers and clinical evaluation of endocrine and hypertensive disorders.

PMID:
42501888
Bibliographic data and abstract were imported from PubMed on 26 Jul 2026.

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