Role of late-onset smoking in super-aged patients with diffuse large B-cell lymphoma: a real-world study in China between 2010 and 2024.

Authors

Zhan Shi, Xi Tang, Qianwen Shen

Published in

PeerJ. Volume 14. Pages e21557. Epub Jul 22, 2026.

Abstract

To investigate the prognostic impact of early-onset smoking history (started smoking before 24 years old) on the survival of Chinese patients aged ≥ 80 years with diffuse large B-cell lymphoma (DLBCL).
Patients aged ≥ 80 years DLBCL with smoke history admitted to our center from 2010 to 2024 were retrospectively enrolled. Patients who started smoking before 24 years old were defined as early-onset smoking group, while who started smoking after the age of < 24 years old were defined as late-onset smoking group. The overall survival (OS), progression-free survival (PFS) and treatment-related complications were compared between the two groups. Cox regression model was used to analyze the prognostic factors.
After follow-up duration of 28.7 months, 68 patients were included. The median OS of early-onset smoking group (n = 29) was 2.3 years, which was significantly lower than that of late-onset smoking group (n = 39, 3.7 years, p < 0.01). Multivariate analysis illuminated that late-onset smoking decreased the risk of death significantly (HR = 0.317, p = 0.031), as well as another risk factor: ECOG < 2 (HR = 0.569, p = 0.042).
Remarkably, late-onset smoking and better performance status portended a favorable prognosis of super-aged patients with lymphoma.

PMID:
42502857
Bibliographic data and abstract were imported from PubMed on 26 Jul 2026.

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