Authors
Lan Li, Jiayu Chen, Jiayi Shao, Lingxiao Ye, Shuya He, Ju Huang, Licai He, Jiawei Cao, Haihua Gu, Guang Wu
Published in
Food science & nutrition. Volume 14. Issue 7. Pages e72111. Epub Jul 25, 2026.
Abstract
Pancreatic cancer is highly lethal, with a five-year survival rate of less than 5%. Gomisin G, extracted from the fruit of Schisandra chinensis, is known for its anti-tumor, anti-inflammatory, and antioxidant properties. However, its specific effects on pancreatic cancer and the underlying mechanisms remain unclear. In this study, we used a colony formation assay to evaluate the impact of Gomisin G on pancreatic cancer cell proliferation and colony formation. Flow cytometry and western blot analyses revealed that Gomisin G induces G1 phase arrest by modulating the expression of cyclin D1, p21, p27, and Rb activity, and triggers apoptosis in pancreatic cancer cells. Using a mouse xenograft model, we found that Gomisin G significantly inhibits the growth of PANC-1 pancreatic tumors. Mechanistically, RNA-seq, western blot, qPCR, and confocal microscopy showed that Gomisin G promotes LATS1-mediated YAP phosphorylation, accelerates YAP protein degradation, reduces its nuclear localization, and down-regulates the mRNA levels of the target genes CTGF and CYR61 in the Hippo-YAP pathway. Overall, our findings suggest that Gomisin G has significant anti-cancer activity against pancreatic cancer and may be a promising candidate for therapeutic development.
PMID:
42502811
Bibliographic data and abstract were imported from PubMed on 26 Jul 2026.
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