When Treatment Becomes a Threat: A Report of a Rare Case of 5-Fluorouracil (5-FU)-Induced Enteritis Mimicking Inflammatory Bowel Disease.

Authors

Andreas Sinanan, Shiva Verma, Yao X Schmidt, Parmod Kumar

Published in

Cureus. Volume 18. Issue 6. Pages e111505. Epub Jun 25, 2026.

Abstract

We report a rare case of 5-fluorouracil-induced enteritis mimicking inflammatory bowel disease (IBD). A 67-year-old man undergoing adjuvant chemotherapy for colon cancer developed profuse diarrhea and fever. Initial findings were suggestive of IBD; however, biopsy findings and clinicopathologic correlation supported a diagnosis of chemotherapy-induced enteritis. Cessation of chemotherapy and initiation of corticosteroids led to resolution of symptoms. Awareness of this rare complication can prevent misdiagnosis and inappropriate treatment.

PMID:
42502532
Bibliographic data and abstract were imported from PubMed on 26 Jul 2026.

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