Acute Seizures and Aphasia in a Patient With Suspected Systemic Lupus Erythematosus: A Diagnostic Puzzle Unveiling Diffuse Hemispheric Glioma, H3 G34-Mutant.

Authors

Xiaojun Li, Ibrahim S Tuna, Marie Rivera-Zengotita, Hans Shuhaiber

Published in

Cureus. Volume 18. Issue 6. Pages e111506. Epub Jun 25, 2026.

Abstract

Diffuse hemispheric glioma, H3 G34-mutant (DHG-H3-G34), is a rare, newly defined WHO grade 4 glioma. Its nonspecific symptoms and radiologic heterogeneity can mimic infectious, autoimmune, and paraneoplastic neurologic disorders, complicating timely diagnosis. We present a case of a 20-year-old man with a history of suspected systemic lupus erythematosus who presented with acute encephalopathy, seizures, and aphasia. He underwent an extensive workup to evaluate for possible encephalitis. Biopsy ultimately revealed the diagnosis of DHG-H3-G34. This case highlights the importance of maintaining a broad differential in young patients with acute neurologic decline. Early consideration of neoplasms is crucial to avoid diagnostic delays in high-grade gliomas.

PMID:
42502511
Bibliographic data and abstract were imported from PubMed on 26 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.