Authors
Zejiang Liu, Maoxia Yang, Kuirong Fu, Zhiyao Yang, Yimin Cai, Cheng Yang, Xiaowei Li, Wen Feng, Lihua Yuan
Published in
Angewandte Chemie (International ed. in English). Pages e7978333. Jul 26, 2026. Epub Jul 26, 2026.
Abstract
In contrast to traditional Möbius molecules characterized by fully conjugated backbones, synthetic amide-linked Möbius-shaped macrocycles represent a hitherto-unreported class of topological architectures. Here we report the rational design of the first hydrogen-bonded Möbius-shaped aramide macrocycles. Central to this design are intramolecular hydrogen bonds within a para-linked aromatic segment, which critically stabilize the conformation and lock the macrocyclic ring into a single-twist topology. Crystallographic analyses unambiguously confirm their single-twisted Möbius-shaped architectures, while LOL-π calculations support sustained electronic delocalization across the macrocyclic backbones. Notably, a reversible topological switching between a single-twisted Möbius-shaped and a planar Hückel-shaped conformation occurs upon the introduction of water clusters, which occupy the central cavity and competitively disrupt the para-linker hydrogen bonds. Furthermore, complexation with chiral amino acids induces characteristic circular dichroism responses, successfully translating host-guest recognition into distinct chiroptical outputs. This work establishes a fully amide-linked macrocyclic platform that enables stimuli-responsive interconversion between Möbius- and Hückel-shaped conformations.
PMID:
42503221
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.
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