Authors
Dominik T Schneider, Kris-Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben-Ami, Ewa Bien, Gianni Bisogno, Ines B Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A Krawczyk, Ricardo Lopez-Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach
Published in
Pediatric blood & cancer. Pages e70571. Jul 27, 2026. Epub Jul 27, 2026.
Abstract
As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference. Complete tumor resection is the cornerstone of treatment, with meticulous attention to preventing tumor spillage. Risk stratification of adjuvant chemotherapy decisions incorporates tumor stage and critical parameters, including histological differentiation and mitotic rate. Optimal patient management requires treatment within cooperative networks providing centralized histopathological review and comprehensive genetic testing, multidisciplinary tumor board evaluation, and prospective registry enrollment to advance knowledge for these exceptionally rare malignancies.
PMID:
42504512
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.
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