Cu(I)-Catalyzed 6-endo-dig Annulation of 2-Bromoaryl Enaminones with Terminal Alkynes: Amine Exchange and Modular Access to Enamine Naphthalenones.

Authors

Xiang Li, Bowei Li, Shimin Xie, Ke Wang, Lebin Su, Yongbo Zhou

Published in

Organic letters. Jul 27, 2026. Epub Jul 27, 2026.

Abstract

A Cu(I)-catalyzed 6-endo-dig annulation of 2-bromoaryl enaminones with terminal alkynes proceeding via Cu(III)-acetylide intermediates affords enamine naphthalenones in up to 94% yield, featuring broad substrate scope and good functional group tolerance. Amine exchange enables the modular incorporation of aniline and diverse secondary amines, significantly expanding molecular diversity.

PMID:
42504568
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.