Photoredox-Catalyzed Divergent Functionalizations of α-Trifluoromethyl Alkenes with Alcohols via Single-Electron Oxidation.

Authors

Xu-Yan Li, Yue Lu, Ke-Jia Xu, Yi-Jing Huang, Jie Liu, Xiao-Lin Chen, Xin-Yi Hong, Lei Fu

Published in

Organic letters. Jul 27, 2026. Epub Jul 27, 2026.

Abstract

A triple selectivity switch in the photocatalytic reaction of α-trifluoromethyl alkenes with alcohols is disclosed. In place of the conventional β-fluoride elimination pathway, a single-electron oxidation manifold enables CF₃-retentive anti-Markovnikov hydroalkoxylation. Switching the reaction atmosphere, photocatalyst, and solvent further diverts the same starting materials to defluorinative esterification and aerobic hydroxylative alkoxylation, providing a divergent synthesis of fluorinated and ester-functionalized structures.

PMID:
42504540
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.

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