[Research progress of gut microbial metabolite succinate in inflammatory diseases].

Authors

Y X Chen, M Niu, Y Du

Published in

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. Volume 60. Issue 7. Pages 1129-1137. Jul 06, 2026.

Abstract

Inflammatory diseases are pathological conditions precipitated by inflammation, with the gut microbiota and its metabolites playing a pivotal role in the inflammatory process. Succinate, a key metabolite generated by gut microorganisms, is implicated not only in the energy metabolism of the tricarboxylic acid cycle but also in the modulation of inflammatory processes via the succinate receptor 1-mediated immune regulatory pathway. This review provides a unified elaboration on the metabolic pathways and biological characteristics of succinate, the detection techniques for succinate, and the potential applications of succinate in the diagnosis and treatment of inflammatory diseases, aiming to provide a scientific basis for the development of relevant diagnosis and treatment strategies.

PMID:
42503938
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.

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