Facile synthesis of isoxazoline-bispirooxindoles via the 1,3-dipolar cycloaddition of nitrile oxides with isoindigos.

Authors

Jian Wang, Song Hu, Chengjian Cao, Heng Yin, Yao Wang, Shuangle Li, Lifu Duan, Chenyi Li, Yulong Li

Published in

Organic & biomolecular chemistry. Jul 27, 2026. Epub Jul 27, 2026.

Abstract

An efficient 1,3-dipolar cycloaddition of nitrile oxides and isoindigos has been disclosed, enabling straightforward access to diverse isoxazoline-bispirooxindoles with vicinal quaternary spirocenters in moderate to excellent yields with high diastereoselectivity. This protocol exhibits a broad substrate scope, excellent functional group compatibility, mild reaction conditions, and operational simplicity. Moreover, a gram-scale reaction followed by subsequent transformations further highlights the practical utility of this approach.

PMID:
42504597
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.

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