Efficacy, safety, and clinical use of second-generation antihistamines for chronic spontaneous urticaria: a comprehensive review.

Authors

Fabià Torres-Betato, Ana María Giménez Arnau, Jorge Spertino

Published in

European journal of dermatology : EJD. Volume 36. Issue 3. Pages 229-234. Jun 01, 2026.

Abstract

Second-generation antihistamines are the mainstay of therapy for chronic spontaneous urticaria. This review summarizes current evidence on their efficacy, safety, and clinical use, including dose escalation and management in specific populations. Recent studies confirm that up-dosing up to four times the standard dose can enhance symptom control without compromising tolerability. Furthermore, these agents demonstrate an excellent cardiovascular safety profile and are generally safe for use in paediatric, elderly, and renally or hepatically impaired patients, with appropriate caution during pregnancy and lactation.

PMID:
42507398
Bibliographic data and abstract were imported from PubMed on 27 Jul 2026.

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